Blood bottles_optIn conclusion, high 28-day mortality of critically ill patients with shock who received high-dose norepinephrine in the ICU does not seem to be associated with underlying disease and comorbid conditions, the cause of shock, or dose or duration of norepinephrine treatment. However, our data suggest that treatment with norepinephrine is futile in patients with high disease severity, metabolic acidemia, and need for cotreatment with high doses of epinephrine. Our results may be helpful in future end-of-life decisions, at least in our here

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