August 5
by Jonathan Downham
In this episode, I explore how sedation practices in critical care have evolved over time — from the routine use of deep, continuous sedation to the early evidence that challenged it. You'll hear about pivotal studies that revealed the risks of over-sedation, the emergence of structured sedation protocols, and the beginnings of a culture shift toward lighter, more patient-centered care.
Key topics:
The rise of continuous sedation in early ICU care
Landmark studies questioning deep sedation
Early implementation of sedation protocols
How sedation culture began to change
Kress et al. (1998). The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation.
Brook et al. (2000). A prospective evaluation of empiric versus protocol-based sedation and analgesia.
Novaes et al. (1999). Stressors in ICU: perception of the patient, relatives, and health care team.
Martin et al. (2001). Sedative and analgesic practice in the intensive care unit: the results of a European survey
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